Skip to content

When you choose to publish with PLOS, your research makes an impact. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.

PLOS BLOGS The Official PLOS Blog

Heart over head? Stages of the heart’s cycle affect neural responses

Optimal windows exist for action and perception during the 0.8 seconds of a heartbeat, according to research from PLOS Biology. The sequence of contraction and relaxation is linked to changes in the motor system and its ability to respond to stimulation – findings that could have implications for treatments for depression and stroke that excite nerve cells. Learn more about the researchers’ findings in our Research Highlights summary below, or you can access the full article in PLOS Biology. 

Researchers uncover a connection between the human heart and brain, revealing distinct time windows tailored for action and perception. Image Credit: Mohamed Ben Ammar, Pixabay (CC0)


The ways in which we perceive and engage with the world are influenced by internal bodily processes such as heartbeats, respiration and digestion. Cardiac activity can influence auditory and visual perception, and touch and sensory perceptions have been shown to be impaired during the systolic phase of the cardiac cycle when blood vessels are briefly distended.

Esra Al of the Max Planck Institute for Human Cognitive and Brain Sciences, Germany, and colleagues, wanted to understand whether there were changes in cortical and corticospinal excitability — the ability to respond to stimuli — across the cardiac cycle. 37 healthy human volunteers aged between 18 and 40 years received a series of transcranial magnetic stimulation (TMS) pulses — non-invasive short magnetic pulses that stimulate nerve cells — above the right side of the brain.

Study Design and Findings

Motor and cortical responses as well as heartbeats were measured during the pulses and the authors found that higher excitability was recorded during the systolic phase. These simultaneous recordings of brain activity, heart activity, and muscle activity, suggest the timing of heartbeats and their neural processing are linked to changes in the excitability of the motor system.

TMS is used in treatments for depression and recovery after stroke. The research raises questions about whether these could be fine-tuned to improve results, as well as contributing to a greater understanding of brain-body interactions in health and in disease.

The authors add, “Intriguingly, this study uncovers a remarkable connection between the human heart and brain, revealing distinct time windows tailored for action and perception.”

Related Posts
Back to top